Scientific papers, patents, and datasets developed within the SusPharma project and by its partners.
Brewing sustainability: Continuous flow Ru-supported hydrochar from bagasse beer waste for renewable N-containing chemicals via reductive amination of biomass-derived platform molecules — Bressi, Viviana; Minio, Francesco; Balu, Alina M.; Rodríguez-Castellón, Enrique; Marrocchi, Assunta; Vaccaro, Luigi; Espro, Claudia; Osman, Sameh M.; Luque, Rafael; Chhabra, Tripti — Sustainable Chemistry and Pharmacy, 37, 101436. https://doi.org/10.1016/j.scp.2024.101436
Synthesis of alcohols: streamlined C1 to Cn hydroxyalkylation through photoredox catalysis — Pasca, Francesco; Gelato, Yuri; Andresini, Michael; Romanazzi, Giuseppe; Degennaro, Leonardo; Colella, Marco; Luisi, Renzo — Chemical Science, 15(29), 11337–11346. https://doi.org/10.1039/d4sc02696a
1-Oxa-2,6-Diazaspiro[3.3]heptane as a New Potential Piperazine Bioisostere – Flow-Assisted Preparation and Derivatisation by Strain-Release of Azabicyclo[1.1.0]butanes — Graziano, Elena; Natho, Philipp; Andresini, Michael; Mastrolorito, Fabrizio; Mahdi, Iktedar; Mesto, Ernesto; Colella, Marco; Degennaro, Leonardo; Nicolotti, Orazio; Luisi, Renzo — Advanced Synthesis & Catalysis, 366(18), 3894-3902. https://doi.org/10.1002/adsc.202400781
Bijel-Based Mesophotoreactor with Integrated Carbon Nitride for Continuous-Flow Photocatalysis — Allasia, Nicolo; Nevskyi, Oleksii; Marelli, Marcello; Plazl, Igor; Albertazzi, Jody; Busini, Valentina; Castiglione, Franca; Rossi, Filippo; Vilé, Gianvito — Chemical Engineering Journal, 499, 155885. https://doi.org/10.1016/j.cej.2024.155885
Hidden Impurities Generate False Positives in Single-Atom Catalyst Imaging — Allasia, Nicolò; Collins, Sean Michael; Ramasse, Quentin Mathieu; Vilé, Gianvito — Angewandte Chemie International Edition, 63(44), e202404883. https://doi.org/0.1002/anie.202404883
Copper Single Atoms Chelated on Ligand-Modified Carbon for Ullmann-type C−O Coupling — Ruta, Vincenzo; Di Liberto, Giovanni; Moriggi, Francesco; Ivanov, Yurii P.; Divitini, Giorgio; Bussetti, Gianlorenzo; Barbera, Vincenzina; Bajada, Mark A.; Galimberti, Maurizio; Pacchioni, Gianfranco; Vilé, Gianvito — ChemSusChem, 17(5), e202301529. https://doi.org/10.1002/cssc.202301529
Sustainable upgrading of glycerol into glycidol and its derivatives under continuous-flow conditions — Sivo, Alessandra; Montanari, Ilaria; Ince, Mert Can; Vilé, Gianvito — Green Chemistry, 26, 7911-7918. https://doi.org/10.1039/D4GC01565G
C(sp^3)–H sulfinylation of light hydrocarbons with sulfur dioxide via hydrogen atom transfer photocatalysis in flow — Nagornii, Dmitrii; Raymenants, Fabian; Kaplaneris, Nikolaos; Noel, Timothy — Nature Communications, 15, 5246. https://doi.org/10.1038/s41467-024-49322-w
Photocatalytic Functionalization of Dehydroalanine-Derived Peptides in Batch and Flow — Kaplaneris, Nikolaos; Akdeniz, Merve; Fillols, Méritxell; Arrighi, Francesca; Raymenants, Fabian; Sanil, Gana; Gryko, Daniel T.; Noel, Timothy — Angewandte Chemie International Edition, 63(19), e202403271. https://doi.org/10.1002/anie.202403271
Benign-by-Design Sustainable Protocol for the Synthesis of Furosemide — Minio, Francesco; Torriente, Airovict Hernandez; Balu, Alina M.; Luigi, Vaccaro; Osman, Sameh M.; Luque, Rafael; Chhabra, Tripti — Sustainable Chemistry and Pharmacy, 39, 101600. https://doi.org/10.1016/j.scp.2024.101600
Pd-N-doped carbons for chemoselective hydrogenation of cinnamaldehyde: Unravelling the influence of particle size and support in multiphase batch and continuous-flow systems — Polidoro, Daniele; Chhabra, Tripti; Rodríguez-Castellón, Enrique; Perosa, Alvise; Luque, Rafael; Rodriguez-Padron, Daily; Selva, Maurizio — Applied Catalysis A: General, 685, 119864. https://doi.org/10.1016/j.apcata.2024.119864
Computer-Aided Retrosynthesis for Greener and Optimal Total Synthesis of a Helicase-Primase Inhibitor Active Pharmaceutical Ingredient — Teixeira, Rodolfo I.; Andresini, Michael; Luisi, Renzo; Benyahia, Brahim — JACS Au, 4(11), 4263-4272. https://doi.org/10.1021/jacsau.4c00624
Non-Parametric Models for Yield Prediction in a Suzuki-Miyaura Coupling — Salazar, Pablo J.; Benyahia, Brahim — Computer Aided Chemical Engineering, 53, 2767-2772. https://doi.org/10.1016/B978-0-443-28824-1.50462-2
Nanostructured Carbon Nitride for Continuous-Flow Trifluoromethylation of (Hetero)arenes — Sivo, Alessandra; Ruta, Vincenzo; Granata, Vittoria; Savateev, Oleksandr; Bajada, Mark A.; Vilé, Gianvito — ACS Sustainable Chemistry & Engineering, 11(13), 5284–5292. https://doi.org/10.1021/acssuschemeng.3c00176
Light-driven C–O coupling of carboxylic acids and alkyl halides over a Ni single-atom catalyst — Bajada, Mark A.; Di Liberto, Giovanni; Tosoni, Sergio; Ruta, Vincenzo; Mino, Lorenzo; Allasia, Nicolò; Sivo, Alessandra; Pacchioni, Gianfranco; Vilé, Gianvito — Nature Synthesis, 2, 1092–1103. https://doi.org/10.1038/s44160-023-00341-3
Forging C−S Bonds on the Azetidine Ring by Continuous Flow Photochemical Addition of Thiols and Disulfides to Azetines — Colella, Marco; Gelato, Yuri; Andresini, Michael; Graziano, Elena; Vilé, Gianvito; Degennaro, Leonardo; Luisi, Renzo — European Journal of Organic Chemistry, 26(33), e202300413. https://doi.org/10.1002/ejoc.202300413
Single-Atom Catalysis in Organic Synthesis — Saptal, Vitthal B.; Ruta, Vincenzo; Bajada, Mark A.; Vilé, Gianvito — Angewandte Chemie International Edition, 62(34), e202219306. https://doi.org/10.1002/anie.202219306
The Role of Surface Complexes in Ketene Formation from Fatty Acids via Pyrolysis over Silica: From Platform Molecules to Waste Biomass — Azizova, Liana R.; Kulik, Tetiana V.; Palianytsia, Borys B.; Ilchenko, Mykola M.; Telbiz, German M.; Balu, Alina M.; Tarnavskiy, Sergiy; Luque, Rafael; Roldan, Alberto; Kartel, Mykola T. — Journal of the American Chemical Society, 145(49), 26592–26610. https://doi.org/10.1021/jacs.3c06966
Sustainable continuous flow synthesis of β-aminocarbonyls via acid-catalyzed hydration of N-Boc-2-azetines — Andresini, Michael; Colella, Marco; Dibenedetto, Roberta Savina; Graziano, Elena; Romanazzi, Giuseppe; Aramini, Andrea; Degennaro, Leonardo; Luisi, Renzo — Reaction Chemistry and Engineering, 8, 3203–3209. https://doi.org/10.1039/D3RE00342F
Structural Effects of Metal Single-Atom Catalysts for Enhanced Photocatalytic Degradation of Gemfibrozil — Ruta, Vincenzo; Sivo, Alessandra; Bonetti, Lorenzo; Bajada, Mark A.; Vilé, Gianvito — ACS Applied Nano Materials, 5(10), 14520–14528. https://doi.org/10.1021/acsanm.2c02859
Aqueous-Based Modified-Released Carrier System — 04/12/2024 — PCT/IB2024/062307
Three-dimensional porous structure and method for producing it — 27/09/2023 — PCT/EP2023/076799
This project has received funding from the European Union – Health and Digital Executive Agency (HADEA) – under the call HORIZON-HLTH-2021-IND-07 – grant agreement No 101057430