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Publications & Outputs

Scientific papers, patents, and datasets developed within the SusPharma project and by its partners.

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  • Synthesis of Aza‐S(VI) Fluorides and Primary Sulfonimidamides from Sulfinylamines — Andresini, Michael; Marraffa, Laura; Şerbetçi, Defne; Natho, Philipp; Colella, Marco; Degennaro, Leonardo; Luisi, Renzo — Advanced Synthesis & Catalysis, 367(2), e202400908. https://doi.org/10.1002/adsc.202400908

  • 3D printed C3N4-based structures for photo-, electro-chemical and piezoelectric applications — Massaroa, Alessio; Nguyen, Kiem; Vogelsang Suárez, David; Glukharev, Artem; Ingrosso, Chiara; Striccoli, Marinella; Kirlioglu, Ahmet Can; Kellici, Suela; Middelkoop, Vesna — Materials Chemistry Frontiers, 9, 2730–2743. https://doi.org/10.1039/D5QM00290G

  • Continuous Flow Decarboxylative Monofluoroalkylation Enabled by Photoredox Catalysis — Pasca, Francesco; Gelato, Yuri; Andresini, Michael; Serbetci, Defne; Natho, Philipp; Romanazzi, Giuseppe; Degennaro, Leonardo; Colella, Marco; Luisi, Renzo — JACS Au, 5(2), 684–692. https://doi.org/10.1021/jacsau.4c00902

  • Shifting Lithium Amide Reactivity to the Radical Domain: Regioselective Radical C−H Functionalization of 3-Iodooxetane for the Synthesis of 1,5-Dioxaspiro[2.3]hexanes — Natho, Philipp; Colella, Marco; Vicenti, Annarita; Romanzzi, Giuseppe; Ullah, Faizan; Sheikh, Nadeem S.; White, Andrew J. P.; Pasca, Francesco; Luisi, Renzo — Angewandte Chemie International Edition, 64(15), e202424346. https://doi.org/10.1002/anie.202424346

  • Tunable Preparation of α-Aminoacyl Fluorides and α-Fluoroamides via Base-Induced Cascade Multiple-Cleavage Processes from Bromodifluorohydrin Reagents and Amines — De Santis, Giulia; Maranzana, Andrea; Lauria, Federica; Spennacchio, Mauro; Andresini, Michael; Purgatorio, Rosa; Colella, Marco; Luisi, Renzo; Degennaro, Leonardo — Advanced Synthesis & Catalysis, 367(17), e70082. https://doi.org/10.1002/adsc.70083

  • Generation and Use of Bicyclo[1.1.0]butyllithium under Continuous Flow Conditions — Graziano, Elena; Colella, Marco; Baumann, Marcus; Luisi, Renzo — Organic Letters, 27(13), 3344–3348. https://doi.org/10.1021/acs.orglett.5c00705

  • Copper Single-Atom Catalyst for Efficient C─S Coupling in Thioether Synthesis — Gazis, Theodore A.; Palit, Shilpa; Cipriano, Luis A.; Allasia, Nicolò; Collins, Sean M.; Ramasse, Quentin M.; Kwon, Ik Seon; Sterrer, Martin; Di Liberto, Giovanni; Vilé, Gianvito — Angewandte Chemie International Edition, 64, 38, e202510632. https://doi.org/10.1002/anie.202510632

  • Photocatalytic C(sp3)–C(sp3) cross-coupling of carboxylic acids and alkyl halides using a nickel complex and carbon nitride — de Vries Ibáñez, Miguel M.; Cipriano, Luis A.; Lagostina, Valeria; Olivati, Andrea; Chiesa, Mario; Petrozza, Annamaria; Di Liberto, Giovanni; Vilé, Gianvito — Nature Communications, 16, 7016. https://doi.org/10.1038/s41467-025-61639-8

  • Structured, Shaped, or Printed Single-Atom Catalysts and Their Applications — Luo, Jiachengjun; Chand, Hushan; Luque, Rafael; Balu, Alina M.; Vilé, Gianvito — Advanced Functional Materials, 35(34), 2424514. https://doi.org/10.1002/adfm.202424514

  • Tracking Charge Dynamics in a Silver Single-Atom Catalyst During the Light-Driven Oxidation of Benzyl Alcohol to Benzaldehyde — Moutsiou, Areti; Olivati, Andrea; Cipriano, Luis A.; Sivo, Alessandra; Collins, Sean M.; Ramasse, Quentin M.; Kwon, Ik Seon; Di Liberto, Giovanni; Kanso, Mohamad; Wojcieszak, Robert; Pacchioni, Gianfranco; Petrozza, Annamaria; Vilé, Gianvito — ACS Catalysis, 15(7), 5601–5613. https://doi.org/10.1021/acscatal.4c05208

  • Sustainability and Techno-Economic Assessment of Batch and Flow Chemistry in Seven Industrial Pharmaceutical Processes — Ince, Mert Can; Benyahia, Brahim; Vilé, Gianvito — ACS Sustainable Chemistry & Engineering, 13(7), 2864–2874. https://doi.org/10.1021/acssuschemeng.4c09289

  • Synergistic Effects in a Nitrogen-Coordinated Zinc Single-Atom Catalyst for Efficient CO₂ Cycloaddition — Chand, Hushan; Allasia, Nicolò; Cipriano, Luis A.; Di Liberto, Giovanni; Kwon, Ik Seon; Zhang, Min; Pacchioni, Gianfranco; Krishnan, Venkata; Vilé, Gianvito — ChemCatChem, 17(5), e202401768. https://doi.org/10.1002/cctc.202401768

  • Resolving the Nanostructure of Carbon Nitride-Supported Single-Atom Catalysts — Allasia, Nicolò; Xu, Shuai; Jafri, Sadaf Fatima; Borfecchia, Elisa; Cipriano, Luis A.; Terraneo, Giancarlo; Tosoni, Sergio; Mino, Lorenzo; Di Liberto, Giovanni; Pacchioni, Gianfranco; Vilé, Gianvito — Small, 21(23), 2408286. https://doi.org/10.1002/smll.202408286

  • Bifunctional Pd-Pt Supported Nanoparticles for the Mild Hydrodeoxygenation and Oxidation of Biomass-Derived Compounds — Ruta, Vincenzo; Cipriano, Luis A.; Di Liberto, Giovanni; Wojcieszak, Robert; Vilé, Gianvito — ChemSusChem, 18(9), e202402641. https://doi.org/10.1002/cssc.202402641

  • Sustainability assessment of single-atom catalysts in the transition to greener chemical processes — Bajada, Mark A.; Tschulkow, Maxim; Vilé, Gianvito — Cell Reports Sustainability, 2(1), 100286. https://doi.org/10.1016/j.crsus.2024.100286

  • A Flexible and Affordable Self-Driving Laboratory for Automated Reaction Optimization — Pilon, Simone; Savino, Elia; Bayley, Oliver; Vanzella, Michael; Claros, Miguel; Siasiaridis, Petros; Liu, Junsong; Lukas, Florian; Damian, Matteo; Tseliou, Vasilis; Intini, Niccolo; Slattery, Aidan; Orduna, Jesus; den Hartog, Tim; Peters, Ron; Gargano, Andrea; Mutti, Francesco; Noel, Timothy — ChemRxiv, 10.26434/chemrxiv-2025-73xqf

  • Digital design and optimization of the integrated synthesis and crystallization process using data-driven approaches — Ma, Yiming; Li, Wei; Liu, Jiaxu; Shang, Gao; Yang, Huaiyu; Gong, Junbo; Nagy, Zoltan K.; Benyahia, Brahim — AIChE Journal, early view. https://doi.org/10.1002/aic.18931

  • Design and optimization of a shared synthetic route for multiple active pharmaceutical ingredients through combined computer aided retrosynthesis and flow chemistry — Teixeira, Rodolfo I.; Benyahia, Brahim — Chemical Engineering Research and Design, 216, 367–375. https://doi.org/10.1016/j.cherd.2025.03.004

  • Simulation of Biomass Processing into Furfural Using ChemCad — Korchuganova, Olena; Liubymova-Zinchenko, Olga; Afonina, Iryna; Kalenyk, Vitalii; Balu, Alina M. — Data-Centric Business and Applications, Lecture Notes on Data Engineering and Communications Technologies, Springer Nature Switzerland, Vol. 240, pp 209–219. https://doi.org/10.1007/978-3-031-81557-7_12

  • SolECOs: a data-driven platform for sustainable and comprehensive solvent selection in pharmaceutical manufacturing — Ma, Yiming; Gao, Shang; Mehta, Neel; Fu, Qinqing; Li, Wei; Benyahia, Brahim — Green Chemistry, 27, 12621–12641. https://doi.org/10.1039/D5GC04176G

  • Strained spiro heterocycles as potential bioisosteres: an update on the synthesis of heteroatom-containing spiro[2.3]hexanes and spiro[3.3]heptanes — Natho, Philipp; Colella, Marco; Luisi, Renzo — Chemical Communications, 61, 6579–6594. https://doi.org/10.1039/D5CC00656B

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  • Brewing sustainability: Continuous flow Ru-supported hydrochar from bagasse beer waste for renewable N-containing chemicals via reductive amination of biomass-derived platform molecules — Bressi, Viviana; Minio, Francesco; Balu, Alina M.; Rodríguez-Castellón, Enrique; Marrocchi, Assunta; Vaccaro, Luigi; Espro, Claudia; Osman, Sameh M.; Luque, Rafael; Chhabra, Tripti — Sustainable Chemistry and Pharmacy, 37, 101436. https://doi.org/10.1016/j.scp.2024.101436

  • Synthesis of alcohols: streamlined C1 to Cn hydroxyalkylation through photoredox catalysis — Pasca, Francesco; Gelato, Yuri; Andresini, Michael; Romanazzi, Giuseppe; Degennaro, Leonardo; Colella, Marco; Luisi, Renzo — Chemical Science, 15(29), 11337–11346. https://doi.org/10.1039/d4sc02696a

  • 1-Oxa-2,6-Diazaspiro[3.3]heptane as a New Potential Piperazine Bioisostere – Flow-Assisted Preparation and Derivatisation by Strain-Release of Azabicyclo[1.1.0]butanes — Graziano, Elena; Natho, Philipp; Andresini, Michael; Mastrolorito, Fabrizio; Mahdi, Iktedar; Mesto, Ernesto; Colella, Marco; Degennaro, Leonardo; Nicolotti, Orazio; Luisi, Renzo — Advanced Synthesis & Catalysis, 366(18), 3894-3902. https://doi.org/10.1002/adsc.202400781

  • Bijel-Based Mesophotoreactor with Integrated Carbon Nitride for Continuous-Flow Photocatalysis — Allasia, Nicolo; Nevskyi, Oleksii; Marelli, Marcello; Plazl, Igor; Albertazzi, Jody; Busini, Valentina; Castiglione, Franca; Rossi, Filippo; Vilé, Gianvito — Chemical Engineering Journal, 499, 155885. https://doi.org/10.1016/j.cej.2024.155885

  • Hidden Impurities Generate False Positives in Single-Atom Catalyst Imaging — Allasia, Nicolò; Collins, Sean Michael; Ramasse, Quentin Mathieu; Vilé, Gianvito — Angewandte Chemie International Edition, 63(44), e202404883. https://doi.org/0.1002/anie.202404883

  • Copper Single Atoms Chelated on Ligand-Modified Carbon for Ullmann-type C−O Coupling — Ruta, Vincenzo; Di Liberto, Giovanni; Moriggi, Francesco; Ivanov, Yurii P.; Divitini, Giorgio; Bussetti, Gianlorenzo; Barbera, Vincenzina; Bajada, Mark A.; Galimberti, Maurizio; Pacchioni, Gianfranco; Vilé, Gianvito — ChemSusChem, 17(5), e202301529. https://doi.org/10.1002/cssc.202301529

  • Sustainable upgrading of glycerol into glycidol and its derivatives under continuous-flow conditions — Sivo, Alessandra; Montanari, Ilaria; Ince, Mert Can; Vilé, Gianvito — Green Chemistry, 26, 7911-7918. https://doi.org/10.1039/D4GC01565G

  • C(sp^3)–H sulfinylation of light hydrocarbons with sulfur dioxide via hydrogen atom transfer photocatalysis in flow — Nagornii, Dmitrii; Raymenants, Fabian; Kaplaneris, Nikolaos; Noel, Timothy — Nature Communications, 15, 5246. https://doi.org/10.1038/s41467-024-49322-w

  • Photocatalytic Functionalization of Dehydroalanine-Derived Peptides in Batch and Flow — Kaplaneris, Nikolaos; Akdeniz, Merve; Fillols, Méritxell; Arrighi, Francesca; Raymenants, Fabian; Sanil, Gana; Gryko, Daniel T.; Noel, Timothy — Angewandte Chemie International Edition, 63(19), e202403271. https://doi.org/10.1002/anie.202403271

  • Benign-by-Design Sustainable Protocol for the Synthesis of Furosemide — Minio, Francesco; Torriente, Airovict Hernandez; Balu, Alina M.; Luigi, Vaccaro; Osman, Sameh M.; Luque, Rafael; Chhabra, Tripti — Sustainable Chemistry and Pharmacy, 39, 101600. https://doi.org/10.1016/j.scp.2024.101600

  • Pd-N-doped carbons for chemoselective hydrogenation of cinnamaldehyde: Unravelling the influence of particle size and support in multiphase batch and continuous-flow systems — Polidoro, Daniele; Chhabra, Tripti; Rodríguez-Castellón, Enrique; Perosa, Alvise; Luque, Rafael; Rodriguez-Padron, Daily; Selva, Maurizio — Applied Catalysis A: General, 685, 119864. https://doi.org/10.1016/j.apcata.2024.119864

  • Computer-Aided Retrosynthesis for Greener and Optimal Total Synthesis of a Helicase-Primase Inhibitor Active Pharmaceutical Ingredient — Teixeira, Rodolfo I.; Andresini, Michael; Luisi, Renzo; Benyahia, Brahim — JACS Au, 4(11), 4263-4272. https://doi.org/10.1021/jacsau.4c00624

  • Non-Parametric Models for Yield Prediction in a Suzuki-Miyaura Coupling — Salazar, Pablo J.; Benyahia, Brahim — Computer Aided Chemical Engineering, 53, 2767-2772. https://doi.org/10.1016/B978-0-443-28824-1.50462-2

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  • Nanostructured Carbon Nitride for Continuous-Flow Trifluoromethylation of (Hetero)arenes — Sivo, Alessandra; Ruta, Vincenzo; Granata, Vittoria; Savateev, Oleksandr; Bajada, Mark A.; Vilé, Gianvito — ACS Sustainable Chemistry & Engineering, 11(13), 5284–5292. https://doi.org/10.1021/acssuschemeng.3c00176

  • Light-driven C–O coupling of carboxylic acids and alkyl halides over a Ni single-atom catalyst — Bajada, Mark A.; Di Liberto, Giovanni; Tosoni, Sergio; Ruta, Vincenzo; Mino, Lorenzo; Allasia, Nicolò; Sivo, Alessandra; Pacchioni, Gianfranco; Vilé, Gianvito — Nature Synthesis, 2, 1092–1103. https://doi.org/10.1038/s44160-023-00341-3

  • Forging C−S Bonds on the Azetidine Ring by Continuous Flow Photochemical Addition of Thiols and Disulfides to Azetines — Colella, Marco; Gelato, Yuri; Andresini, Michael; Graziano, Elena; Vilé, Gianvito; Degennaro, Leonardo; Luisi, Renzo — European Journal of Organic Chemistry, 26(33), e202300413. https://doi.org/10.1002/ejoc.202300413

  • Single-Atom Catalysis in Organic Synthesis — Saptal, Vitthal B.; Ruta, Vincenzo; Bajada, Mark A.; Vilé, Gianvito — Angewandte Chemie International Edition, 62(34), e202219306. https://doi.org/10.1002/anie.202219306

  • The Role of Surface Complexes in Ketene Formation from Fatty Acids via Pyrolysis over Silica: From Platform Molecules to Waste Biomass — Azizova, Liana R.; Kulik, Tetiana V.; Palianytsia, Borys B.; Ilchenko, Mykola M.; Telbiz, German M.; Balu, Alina M.; Tarnavskiy, Sergiy; Luque, Rafael; Roldan, Alberto; Kartel, Mykola T. — Journal of the American Chemical Society, 145(49), 26592–26610. https://doi.org/10.1021/jacs.3c06966

  • Sustainable continuous flow synthesis of β-aminocarbonyls via acid-catalyzed hydration of N-Boc-2-azetines — Andresini, Michael; Colella, Marco; Dibenedetto, Roberta Savina; Graziano, Elena; Romanazzi, Giuseppe; Aramini, Andrea; Degennaro, Leonardo; Luisi, Renzo — Reaction Chemistry and Engineering, 8, 3203–3209. https://doi.org/10.1039/D3RE00342F

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  • Structural Effects of Metal Single-Atom Catalysts for Enhanced Photocatalytic Degradation of Gemfibrozil — Ruta, Vincenzo; Sivo, Alessandra; Bonetti, Lorenzo; Bajada, Mark A.; Vilé, Gianvito — ACS Applied Nano Materials, 5(10), 14520–14528. https://doi.org/10.1021/acsanm.2c02859

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  • Aqueous-Based Modified-Released Carrier System — 04/12/2024 — PCT/IB2024/062307

  • Three-dimensional porous structure and method for producing it — 27/09/2023 — PCT/EP2023/076799

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This project has received funding from the European Union – Health and Digital Executive Agency (HADEA) – under the call HORIZON-HLTH-2021-IND-07 – grant agreement No 101057430

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